The paper identifies HECTD4 as a tumor and metastasis suppressor that targets COX-2 for degradation, with COX-2 stabilization driving pro-tumorigenic effects in breast cancer.

Proceedings of the National Academy of Sciences · Aug 6, 2025Peer-reviewedCancer Biology

Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product

Avanish Mishra, Shih‐Bo Huang, Taronish D. Dubash, Risa Burr, Jon F., Ben S. Wittner, Quinn E. Cunneely, Victor R. Putaturo, Akansha Deshpande, Ezgi Antmen, Kaustav A. Gopinathan, Keisuke Otani, Yoshiyuki Miyazawa, Ji Eun Kwak, Sara Y. Guay, , Mehmet Toner

This study uses high-throughput microfluidic technology to enrich CTCs from large blood volumes, enabling detailed molecular and morphological analysis of tumor cells in metastatic cancer patients.

Nature Communications · Jan 2, 2025Peer-reviewedBioengineering

A Pooled Electronic Consultation Program to Improve Access to Genetics Specialists

Emma K. Folkerts, Renée C. Pelletier, Daniel C. Chung, Susan A. Goldstein, Douglas Scott Micalizzi, Kristen Mahoney Shannon, David A. Sweetser, Eugene Wong, Heidi L. Rehm, Leland E. Hull

A pooled electronic consultation program improved access to genetics specialists by triaging 153 requests and providing actionable recommendations in 3.2 days on average.

Genetics in Medicine Open · Jan 1, 2023Peer-reviewedGenetic & Genomic Medicine