William S. Schierding

This study uses Mendelian randomization with spatial gene networks to identify causal genes and shared/distinct drivers of risk for melanoma, BCC, and SCC.

The paper identifies melanoma-specific mutation hotspots in non-coding regions that affect gene expression and suggest novel candidate driver genes.

The paper identifies 123 genomic variants that regulate RAD21 expression, both locally and distantly, and links them to cancer-related genes and Sp2 transcription factor binding sites.

This study identifies gene regulatory networks influenced by Parkinson's disease risk SNPs using eQTL and chromosomal conformation data across multiple tissues.

The paper uses machine learning to identify six genetic variants and tissue-specific eQTL effects linked to Parkinson's disease risk.

The paper constructs a liver-specific gene regulatory network to identify genetic links between NAFLD and co-occurring conditions, revealing shared regulatory mechanisms.

This study identifies shared genetic mechanisms across 18 autoimmune diseases by integrating chromatin contact, expression quantitative trait loci, and protein-protein interaction data.

The paper identifies transcriptional connections and functional links between cohesin genes and disease-relevant pathways, showing their intolerance to expression variation.

The paper identifies shared regulatory pathways between grip strength and neuromuscular disorders using eQTL and Hi-C data, revealing common drug targets and biological mechanisms.

The paper identifies regulatory elements within the ACE2 locus that control host gene expression, suggesting they may contribute to a pro-viral environment for SARS-CoV-2.

This study integrates chromatin interactions and genetic data to identify SNP-gene-metabolite associations across multiple tissues.

The paper identifies genetic drivers of multimorbidities by analyzing chromatin interactions and eQTL data to uncover regulatory interactions across multiple phenotypes.

The paper identifies genetic variants associated with post-term birth in Northern Finland cohorts and links some to gene expression changes.