Author

Karine Guyot

InsermORCID 0000-0001-5673-9670Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 1 Organism:rat· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Jean‐Charles LambertiD· 3 shared Philippe AmouyeliD· 3 shared Alexandre PelletieriD· 2 shared Ana Raquel Melo de FariasiD· 2 shared Audrey CouloniD· 2 shared Benjamin Grenier‐BoleyiD· 2 shared Chloé Najdek· 2 shared Devrim KilinciD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Jean‐Charles LambertORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

GeneticsbioRxivPreprintOct 30, 2026

The Alzheimer's disease-associated rs28834970 variant in PTK2B impairs electrical activity and regulates Tau phosphorylation and APP processing in human neuronal cultures

Nina lannette-Weimann, Marlène Huyvaert, Floriane Limoge…·Julie Dumont

This study identifies the rs28834970 variant in PTK2B as a risk factor for Alzheimer's disease, showing it impairs PYK2 function, increases Tau phosphorylation, and alters APP processing in human neuronal cultures.

DOI 10.64898/2026.10.26.761842

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 29, 2024

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks

Audrey Coulon, Florian Rabiller, Mari Takalo…·Jean‐Charles Lambert

This study shows that PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease-related markers in neurons.

3 citations

rathuman

𝕏 PostBluesky

NeurosciencebioRxivPreprintJan 18, 2022

The Alzheimer's disease risk gene BIN1 modulates neural network activity via the regulation of L-type calcium channel expression in human-induced neurons

Orthis Saha, Ana Raquel Melo de Farias, Alexandre Pelletier…·Marcos R. Costa

This study shows BIN1 regulates L-type calcium channels in neurons, affecting calcium homeostasis and electrical activity, and links these changes to Alzheimer's disease pathology.

DOI 10.1101/2022.01.18.476601

humanscRNA-seq

𝕏 PostBluesky