Author

Audrey Coulon

InsermORCID 0000-0002-2045-8364Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Approach:experimental assay· 1 Organism:rat· 1

Frequent Co-Authors

Benjamin Grenier‐BoleyiD· 3 shared Jean‐Charles LambertiD· 3 shared Julie DumontiD· 3 shared Julien ChapuisiD· 3 shared Philippe AmouyeliD· 3 shared Chloé Najdek· 2 shared Devrim KilinciD· 2 shared Florian RabilleriD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Benjamin Grenier‐BoleyORCID

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3 papers

Recent·Most cited

The Alzheimer's disease-associated rs28834970 variant in PTK2B impairs electrical activity and regulates Tau phosphorylation and APP processing in human neuronal cultures

Nina lannette-Weimann, Marlène Huyvaert, Floriane Limoge, Morgane Lemaire, Vance Difan Gao, Florence Maurier, Karine Guyot, Charlotte Henocq, Audrey Coulon, Valérie Buiche, Florian Rabiller, Nad’a Majerníková, Pauline Walle, Sophie Desnoulez-Salomé, Bruno Neiva-Queirós, , Julie Dumont

This study identifies the rs28834970 variant in PTK2B as a risk factor for Alzheimer's disease, showing it impairs PYK2 function, increases Tau phosphorylation, and alters APP processing in human neuronal cultures.

bioRxiv · Oct 30, 2026 · PreprintGenetics

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks

Audrey Coulon, Florian Rabiller, Mari Takalo, Avishek Roy, Alexandre Pelletier, Henna Martiskainen, Dolores Siedlecki‐Wullich, Nina Lannette-Weimann, Naďa Majerníková, Arthur Grenon, Vance Difan Gao, Anaël Erhardt, Anne Pernodet, Morgane Lemaire, Floriane Limoge, , Jean‐Charles Lambert

This study shows that PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease-related markers in neurons.

bioRxiv · Apr 29, 2024 · PreprintNeuroscience

Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.

Fanny Eysert, Audrey Coulon, Emmanuelle Boscher, Anaïs-Camille Vreulx, Amandine Flaig, Tiago Mendes, Sandrine Hughes, Benjamin Grenier‐Boley, Xavier Hanoulle, Florie Demiautte, Charlotte Bauer, Mikael Marttinen, Mari Takalo, Philippe Amouyel, Shruti Desai, , Julien Chapuis

The paper identifies FERMT2 as a key modulator of axon guidance and synaptic plasticity in an APP-dependent manner, linking its genetic risk variant to Alzheimer's disease through miRNA regulation.

Molecular Psychiatry · Nov 3, 2020Peer-reviewedNeuroscience