Marcos R. Costa

This study examines the molecular and functional effects of TDP-43 loss in human induced neurons, revealing cell-type-specific gene expression and splicing changes, and a hyperexcitable phenotype in both glutamatergic and cholinergic motor neurons.

This study shows that PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease-related markers in neurons.

This study shows BIN1 regulates L-type calcium channels in neurons, affecting calcium homeostasis and electrical activity, and links these changes to Alzheimer's disease pathology.

This study shows that BIN1 isoform1 causes early endosome defects and neurodegeneration in Drosophila and human neurons, linking it to Alzheimer's disease pathology.

The paper identifies Sox9 as a key regulator of neurogenic behavior in radial glial progenitors, showing its role in maintaining stem cell identity and generating upper-layer neurons.

This study shows that adult mouse hippocampal progenitors can change lineage fate in response to chemoconvulsants, with KA promoting astrogliogenesis and PL favoring neurogenesis.

The paper develops a microfluidic co-culture model to study Aβ1-42-induced synaptotoxicity and shows Pyk2 overexpression in postsynaptic neurons protects against it.

This study shows that Neurogenin2 can reprogram Muller glia into retinal ganglion cell-like neurons, with efficiency comparable to ASCL1 but with distinct gene expression outcomes.