Author

Orthis Saha

InsermORCID 0000-0003-2459-060XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexandre PelletieriD· 3 shared Ana Raquel Melo de FariasiD· 3 shared Jean‐Charles LambertiD· 3 shared Marcos R. CostaiD· 3 shared Philippe AmouyeliD· 3 shared Amélie BonnefondiD· 2 shared Arnaud CarrieriD· 2 shared Bruna Soares LandeiraiD· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Alexandre PelletierORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintApr 29, 2024

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks

Audrey Coulon, Florian Rabiller, Mari Takalo…·Jean‐Charles Lambert

This study shows that PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease-related markers in neurons.

3 citations

𝕏 PostBluesky

NeurosciencebioRxivPreprintJan 18, 2022

The Alzheimer's disease risk gene BIN1 modulates neural network activity via the regulation of L-type calcium channel expression in human-induced neurons

Orthis Saha, Ana Raquel Melo de Farias, Alexandre Pelletier…·Marcos R. Costa

This study shows BIN1 regulates L-type calcium channels in neurons, affecting calcium homeostasis and electrical activity, and links these changes to Alzheimer's disease pathology.

DOI 10.1101/2022.01.18.476601

𝕏 PostBluesky

NeuroscienceActa Neuropathologica CommunicationsPeer-reviewedJan 8, 2022

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects

Erwan Lambert, Orthis Saha, Bruna Soares Landeira…·Pierre Dourlen

This study shows that BIN1 isoform1 causes early endosome defects and neurodegeneration in Drosophila and human neurons, linking it to Alzheimer's disease pathology.

65 citationstop 1%

Drosophilaproteomics

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