Endosomal hyper-acidification via proton-activated chloride channel deletion in neurons impairs AMPA receptor endocytosis and LTD
Kevin Yi Chen, Junhua Yang, Bian Liu, Chaohua Jiang, Nicholas Koylass, Zhe Zhang, Shuying Sun, Richard L. Huganir, Zhaozhu Qiu
This study shows that deletion of the proton-activated chloride channel in neurons leads to endosomal hyper-acidification, impairing AMPA receptor endocytosis and long-term depression.
bioRxiv · Sep 27, 2024 · PreprintNeuroscience