Nicholas Koylass

This study shows that increased microbial exposure in adult mice worsens allergic airway inflammation, while early exposure does not have the same effect.

This study identifies PSA as an inhibitory auxiliary subunit of VRACs, showing its regulatory role is independent of aminopeptidase activity.

This study shows that the proton-activated chloride channel inhibits SARS-CoV-2 entry by blocking endosomal acidification and the cathepsin-dependent pathway.

This study identifies the proton-activated chloride channel as a regulator of phagosome maturation and bacterial killing in peritoneal macrophages, showing its role in immune responses.

The paper determines the structure of the TARP subunit γ2 using cryo-EM and identifies structural motifs that differentiate TARPs from claudins and explain subfamily variations.

This study shows that deletion of the proton-activated chloride channel in neurons leads to endosomal hyper-acidification, impairing AMPA receptor endocytosis and long-term depression.