Junhua Yang

This study shows that deletion of the proton-activated chloride channel in neurons leads to endosomal hyper-acidification, impairing AMPA receptor endocytosis and long-term depression.

This study identifies KAT6A's role in regulating synaptic plasticity and memory through RSPO2/Wnt signaling in hippocampal CA3, linking KAT6A deficiency to cognitive impairments.

This paper describes a new non-mosaic humanized mouse model of Down syndrome with a nearly complete copy of the long arm of human chromosome 21.