Michael Lee

This paper introduces SBX, a single-molecule sequencing technology that improves nanopore sequencing accuracy and scalability by encoding DNA into Xpandomers with high signal-to-noise reporter codes.

This study identifies spaceflight-induced changes in gut microbiota and host gene expression in mice, suggesting altered host-microbiome interactions contribute to spaceflight-related pathologies.

The paper introduces an interactive method for analyzing gene-level phylogenies in microbial evolution, enabling visualization and comparison of gene histories across bacterial strains.

The paper identifies candidate prions across all three domains of life and finds conserved functions suggesting ancient roles in adaptation and evolution.

The paper identifies sequence features of retrotransposons that influence epigenetic variability in DNA methylation, particularly in IAPs, by affecting KZFP and ZF-CxxC protein interactions.

This study analyzes over 7,000 SARS-CoV-2 datasets to reveal genomic diversity, showing iSNVs and small indels drive variation, and highlights implications for qRT-PCR and transmission tracking.

The paper describes a standardized RNA-Seq pipeline for spaceflight data, enabling reproducible analysis of gene expression changes in astronauts and organisms exposed to spaceflight.

This study evaluates genomic prediction models with genotype by environment interaction for kernel zinc concentration in maize, finding that models incorporating G x E interactions improve prediction accuracy.

This study shows hyperinsulinemia increases histone acetylation and promotes tumor growth in TNBC via the PI3K/AKT/mTOR pathway.

GToTree provides a command-line tool to generate phylogenomic trees from genomic data, simplifying the workflow for non-bioinformaticians.