Daniel B. Reeves

The paper models how delayed immune responses and prolonged infections increase the transmission risk of SARS-CoV-2 variants with fitness-enhancing mutations.

The paper models in vivo functions of five anti-HIV bnAbs using clinical trial data to quantify neutralization, Fc-mediated killing, and resistance.

The paper analyzes HIV breakthrough virus populations in antibody-mediated prevention trials, finding high rates of multilineage infections and recombination under VRC01 treatment.

This study identifies VRC01-mediated viral escape mutations in HIV-infected participants from antibody-mediated prevention trials, showing that VRC01 can select for escape variants with cross-resistance to other CD4bs bnAbs.

Q4ddPCR improves HIV reservoir quantification by targeting four conserved regions, achieving 95% accuracy and revealing clonal dynamics not detectable by IPDA.

This paper identifies highly-conserved CRISPR guide RNAs for HIV cure and models the impact of viral diversity on therapeutic success.