Francisco Javier Gil-Bea

Criticality-related dynamics accompany long-term functional decline in primary cortical MEA cultures

This study tracks long-term electrophysiological changes in rat cortical cultures, identifying criticality metrics as predictors of network survival and decline.

Modulation of retroviral capsid assembly halts ARC-mediated TDP-43 intercellular spreading

This study shows that ARC acts as a retroviral-like capsid for TDP-43 spreading in ALS and FTD, and that Lenacapavir blocks this process.

Computational Analysis of ELOVL6 Structure and Inhibition for Rational Drug Design

This study uses computational methods to analyze ELOVL6 structure and inhibition, identifying key residues and binding pathways for drug design.

Assessment of the pharmacological and safety profile of the small molecule MP-004 after topical eye drops administration

This study evaluates the pharmacological and safety profile of MP-004 after topical eye drops in mice, rabbits, and pigs, showing effective retinal concentrations and minimal systemic exposure.

Lipid Dysregulation Unveil the Intricate Interplay of Lysosomal and Mitochondrial Changes in Frontotemporal Dementia with GRN Haploinsufficiency

This study shows that GRN haploinsufficiency in FTD causes lysosomal and mitochondrial dysfunction, lipid metabolism changes, and autophagy impairment, which may contribute to disease pathogenesis.

Novel FKBP12 ligand promotes functional improvement in SOD1-G93A ALS mice

This study tests a novel FKBP12 ligand, MP-010, in ALS mice, showing improved motor function, preserved motor neurons, and extended lifespan.