BiophysicsbioRxivPreprint
Caspase prime-side active-site characterization with non-hydrolyzable peptides assists in the design of a caspase-7-selective irreversible probe.
Angelo Solania, Janice H. Xu, Dennis W. Wolan
The paper designs and characterizes non-hydrolyzable peptidomimetic inhibitors to selectively probe caspase-7 over caspase-3 by exploiting differences in their prime-side active-site architecture.
DOI 10.1101/2024.01.30.578085