Kun Zhang

This study shows that Daraxonrasib (RMC-6236) effectively targets RAS-mutant neuroblastoma by inhibiting MAPK signaling and enhancing cell death.

This study identifies PIAS1-mediated SUMOylation of EBNA1 as critical for suppressing EBV lytic replication and enhancing episome maintenance.

This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.