Richard J. A. Goodwin

The paper identifies differentially expressed genes in specific brain regions of germ-free mice, highlighting microbiome influence on brain gene expression and potential relevance to neurological disease.

This study shows that combining hypoxia-activated prodrugs with chemotherapy disrupts metabolic resistance mechanisms in osteosarcoma by targeting ferroptosis, glycolysis, and survival pathways.

This study investigates the systemic effects of microbiome-derived carnitine analogues in mice, showing carnitine depletion and mitochondrial dysfunction due to inhibition of carnitine biosynthesis.

This study uses spatial biology to identify intestinal and systemic molecular drivers of inflammation in DSS-treated mice, revealing new insights into IBD-related systemic effects.

This study investigates how gut microbiome-derived metabolites affect intestinal barrier integrity and immune cell responses to infection at the cellular level.

The paper evaluates spatial metabolomics protocols and technologies, showing extensive metabolite coverage and comparable results across imaging MS methods.

The paper uses deep learning with t-SNE to analyze large datasets and overcome size limitations in bioinformatics.

An open-source cloud engine annotates imaging mass spectrometry data at controlled false discovery rate; publicly shared results reached over 3200 datasets and 6 million metabolite images by January 2019.