Heather Hulme

Mapping gene expression across the microbiome-gut-brain axis of germ- and specific pathogen-free mice

The paper identifies differentially expressed genes in specific brain regions of germ-free mice, highlighting microbiome influence on brain gene expression and potential relevance to neurological disease.

SMEW: An interactive multi-scale toolkit for cross-condition and network-based analysis of spatial metabolomics data

SMEW provides a code-free, interactive platform for analyzing spatial metabolomics data across multiple scales and conditions to identify metabolic patterns and biological pathways.

Inhibition of systemic mammalian metabolism by carnitine mimics from the gut microbiota

This study investigates the systemic effects of microbiome-derived carnitine analogues in mice, showing carnitine depletion and mitochondrial dysfunction due to inhibition of carnitine biosynthesis.

Multimodal profiling unveils a reversible breast basal-like cell state in AKT-inhibitor resistant tumours

This study identifies a reversible basal-like cell state in AKT-inhibitor resistant triple negative breast cancer using multimodal profiling and lineage tracing.

Spatial mapping of dextran sodium sulphate-induced intestinal inflammation and its systemic effects

This study uses spatial biology to identify intestinal and systemic molecular drivers of inflammation in DSS-treated mice, revealing new insights into IBD-related systemic effects.