Richard Burchmore

Single-cell transcriptomics reveals life cycle and cell cycle gene expression dynamics during in vitro growth of two Leishmania species

This study uses single-cell transcriptomics to analyze life cycle and cell cycle gene expression dynamics in two Leishmania species during in vitro growth, revealing developmental endpoints and cell cycle-related gene expression patterns.

Mapping gene expression across the microbiome-gut-brain axis of germ- and specific pathogen-free mice

The paper identifies differentially expressed genes in specific brain regions of germ-free mice, highlighting microbiome influence on brain gene expression and potential relevance to neurological disease.

Inhibition of systemic mammalian metabolism by carnitine mimics from the gut microbiota

This study investigates the systemic effects of microbiome-derived carnitine analogues in mice, showing carnitine depletion and mitochondrial dysfunction due to inhibition of carnitine biosynthesis.

Nuclear proteome analysis reveals spatial and temporal compartmentalization of metabolic enzymes during Trypanosoma cruzi cell cycle

This study identifies phase-specific nuclear proteome changes in Trypanosoma cruzi during the cell cycle, revealing metabolic enzymes' role in nuclear processes.

Spatial mapping of dextran sodium sulphate-induced intestinal inflammation and its systemic effects

This study uses spatial biology to identify intestinal and systemic molecular drivers of inflammation in DSS-treated mice, revealing new insights into IBD-related systemic effects.

Pulse of α-2-macroglobulin and lipocalin-1 in the pregnant uterus of European polecats (Mustela putorius) at the time of implantation

The paper identifies changes in uterine secretory proteins in European polecats during implantation, highlighting increased α-2-macroglobulin and lipocalin-1.