Naomi X.Y. Ling

This study identifies an autoinhibitory mechanism in the N-terminal extension of AMPKγ3 that regulates basal activity in skeletal muscle, offering a target for T2DM therapies.

The paper uses long-read sequencing to map Drp1 transcript variants in human and mouse tissues, revealing tissue-specific expression and isoform-dependent mitochondrial fission activity.

This paper refines a radiolabelled assay for measuring glycogen phosphorylase activity in skeletal muscle, revealing sex-specific variations and improving assay reliability across mouse strains.

This study shows that metrnl improves glucose tolerance in type 2 diabetes by activating the AMPK pathway and enhancing GLUT4 transcription.