Maria‐Luisa Alegre

immgenT creates a comprehensive T-cell molecular atlas across mouse organs and disease states, identifying 8 lineages and 107 clusters using deep generative models and integrating external datasets.

This study compares CD4+ T cell transcriptional states in transplant rejection and pregnancy tolerance using scRNA-seq, identifying distinct Tfh and Treg signatures.

This study shows that A2-specific CAR Tregs synergize with anti-CD154 to promote graft survival in haplo-mismatched heart transplants by inhibiting donor-specific immune responses.