Ananda W. Goldrath

SpatialTRACE extends anatomical annotations from a few structures to tissue-wide maps using graph and image-based models in spatial transcriptomics and microscopy.

immgenT creates a comprehensive T-cell molecular atlas across mouse organs and disease states, identifying 8 lineages and 107 clusters using deep generative models and integrating external datasets.

The paper establishes immgenT-CD8 as a comprehensive reference for mouse CD8αβ T cell differentiation states across diverse immunological contexts.

FITdb integrates and harmonizes functional genomics datasets from immune cell studies to enable cross-study comparisons and gene function analysis.

The paper identifies diverse human antibody-secreting cell subsets using multi-omic methods and shows their distinct functional and spatial characteristics.

This study shows how multiple myeloma and its treatment alter the bone marrow niche, impairing immune reconstitution and vaccine responses, with mRNA vaccines showing better efficacy than influenza vaccines.

This study identifies HIF-1α+ CD4 T cells as key coordinators of a tissue-resident immune network in the lung during infection and cancer.

The paper creates a cell-type-specific IFN response atlas to distinguish IFN-I and IFN-II activities in human immune cells across diseases.

This study identifies proteostasis as critical for T cell differentiation potential and tumor-infiltrating lymphocyte function, showing that maintaining E3 ubiquitin ligases improves anti-tumor responses.

This study uses multi-omic profiling to analyze immune cell dynamics in healthy adults over time, finding age-related transcriptional changes in T cells and impaired memory B cell responses in older adults.

This study identifies two distinct CD4+ T cell populations in inflamed lungs, showing that TCF1+ progenitor cells in tertiary lymphoid structures drive Th2 responses in allergic disease.

The paper identifies immune alterations preceding rheumatoid arthritis onset and provides tools for dataset exploration.

The paper identifies TCR-V gene usage patterns in T cells sorted by anti-TCR mAbs using single-cell RNAseq and finds enriched ERV1-family LTR expression in specific TRBV regions.

The paper examines T cell changes in mammary glands during pregnancy and lactation, finding an expansion of T effector cells and similarities to intestinal T cells.

The paper investigates how spatial location influences the functional diversity of memory CD8 T cells by analyzing their transcriptomes in the small intestine.

The paper identifies key transcription factors in immune cell specification using integrated transcriptomic and epigenomic data across mouse and human cell types.