Christopher F Carpenter

scBaseCount is a single-cell RNA sequencing database that automates metadata extraction and data processing using AI, offering a large, standardized collection of gene expression data across multiple organisms and tissues.

The paper systematically identifies post-transcriptional regulatory modules by integrating multimodal data on RBP interactions and functions.

The paper identifies 245 putative RNA structural switches in the human transcriptome using a computational and experimental approach, validates one with DMS-MaPseq and cryo-EM, and shows its regulation by trans factors and nonsense-mediated decay.