Shaopu Zhou

The paper identifies RNF8 and MIS18A as chromatin organizers that modulate intratumoral heterogeneity in breast cancer, affecting therapeutic sensitivity and metastasis.

The paper uses an image-based CRISPR screen to show splicing regulates HP1α condensates through RNA-chromatin interactions, affecting heterochromatin organization and stress response genes.

The paper systematically identifies post-transcriptional regulatory modules by integrating multimodal data on RBP interactions and functions.

The paper introduces Mach-1, an RNA foundation model that predicts transcriptome architecture from DNA sequence, validated through experimental perturbations and CRISPR editing.

The paper identifies 245 putative RNA structural switches in the human transcriptome using a computational and experimental approach, validates one with DMS-MaPseq and cryo-EM, and shows its regulation by trans factors and nonsense-mediated decay.

The paper identifies cell fate determinants in Pax7-expressing somitic mesoderm by analyzing single-cell RNA profiles, revealing lineage-specific markers, transcription factors, and signaling pathways.