Andrey Buyan

Knockdown of the long non-coding RNA DNAAF3-AS1 activates the p53 pathway and remodels the H3K36me3 landscape

This study shows that knocking down DNAAF3-AS1 reduces gene-body H3K36me3, activates the p53 pathway, and alters promoter usage in apoptosis-related genes.

New insight into the RNA-chaperon activity of nucleobindin 1

The paper identifies three RNA-binding regions in NUCB1 and demonstrates its ability to interact with two RNA fragments, suggesting a role in RNA-chaperone activity.

Rare gain-of-function regulatory mutations explain the missing heritability of bicuspid aortic valve

The paper identifies rare gain-of-function regulatory mutations as significant contributors to the missing heritability of bicuspid aortic valve.

A Joint Promoterome-Proteome Atlas Highlights the Molecular Diversity of Human Skeletal Muscles

The paper creates a promoterome and proteome atlas of human skeletal muscles, revealing molecular diversity and identifying key transcription factors and genetic variants associated with muscle traits.

Transcript-wide m6A methylation defines the efficiency of the cap-independent translation initiation

The paper investigates how global m6A methylation levels affect cap-independent translation efficiency, showing that total m6A levels, not specific localization, determine this process.

A novel class of non-coding variants driving DNA double-strand breaks is associated with complex genetic diseases

The paper identifies a new class of non-coding variants, dsbSNPs, that modulate DNA double-strand break frequency and are enriched in GWAS associations for complex diseases.

Statistical framework for calling allelic imbalance in high-throughput sequencing data

The paper introduces MIXALIME, a statistical framework for detecting allele-specific events in sequencing data, and demonstrates its application in constructing an atlas of allele-specific chromatin accessibility.

Codebook: sequence specificity and genomic binding of poorly-characterized human transcription factors

The paper systematically determines the sequence specificity of 332 poorly characterized human transcription factors, identifying over 4,000 experiments and revealing tens of thousands of new TF binding sites.

Systematic Identification of Post-Transcriptional Regulatory Modules

The paper systematically identifies post-transcriptional regulatory modules by integrating multimodal data on RBP interactions and functions.

Systematic identification of cis-interacting lncRNAs and their targets

The paper identifies cis-interacting lncRNAs and their targets using RNA-chromatin and Hi-C data across 18 human cell types.