Gina M. Calabrese

The paper uses single-cell transcriptomics in mice to identify cell type-specific networks and prioritize genes associated with human bone mineral density GWAS findings.

The paper evaluates a scalable approach using scRNA-seq to generate cell-type specific transcriptomic profiles of mesenchymal lineage cells from mouse bone marrow-derived stromal cells.

The paper identifies 512 potentially causal genes for bone mineral density using TWAS and eQTL colocalization, with PPP6R3 validated in mice.

The paper uses Diversity Outbred mice to analyze bone traits and identify novel genes associated with bone strength, informing human GWAS findings.

The paper identifies a core gene module for bone mineral density by integrating co-expression networks and GWAS data, revealing four novel causal genes.

The paper identifies Zbtb40 as a regulator of osteoblast activity and bone mass through genetic analysis in mice, showing reduced BMD and mineralization upon Zbtb40 knockdown.

This study identifies Lhfp as a regulator of bone mass through GWAS and systems genetics in mice, showing its role in osteoblast differentiation and increased BMD.