Basel Maher Al-Barghouthi

The paper evaluates a scalable approach using scRNA-seq to generate cell-type specific transcriptomic profiles of mesenchymal lineage cells from mouse bone marrow-derived stromal cells.

The paper identifies 512 potentially causal genes for bone mineral density using TWAS and eQTL colocalization, with PPP6R3 validated in mice.

The paper uses Diversity Outbred mice to analyze bone traits and identify novel genes associated with bone strength, informing human GWAS findings.

The paper identifies 58 long non-coding RNAs potentially responsible for BMD GWAS associations by combining allelic imbalance, TWAS, and eQTL colocalization analyses.

This study identifies Lhfp as a regulator of bone mass through GWAS and systems genetics in mice, showing its role in osteoblast differentiation and increased BMD.