Brajabandhu Pradhan

The paper identifies two polymorphs of an independent amyloid core in the C-terminal region of medin, showing it has multiple aggregation-prone regions.

This study shows human macrophages and microglia actively produce Aβ42 fibrils, which seed amyloid plaques and tau aggregation, and this process is influenced by genetic factors like TREM2.

This study determines the cryo-EM structures of Aβ40 and medin fibrils in vitro, revealing polymorphic remodeling and mixed amyloid interactions.