Bart De Strooper

This study identifies TRPML1 loss as a cause of lysosomal calcium failure and astrocyte dysfunction in Alzheimer's Disease, showing that restoring TRPML1 can prevent disease progression.

The paper reconstructs the Alzheimer's disease neurodegenerative cascade in human L2/3 excitatory neurons using single-nucleus RNA sequencing data from multiple datasets.

This study shows human macrophages and microglia actively produce Aβ42 fibrils, which seed amyloid plaques and tau aggregation, and this process is influenced by genetic factors like TREM2.

This paper develops a pair of congenic mice for PET/CT imaging of transplants using anti-TfR nanobodies, showing their ability to track transplanted cells without genetic modification.

This study shows Lecanemab reduces amyloid pathology by activating microglia through Fc fragment engagement, enhancing phagocytosis and lysosomal degradation.

The paper introduces a proteomic tool to identify protein markers for human microglial states and validates their utility in purification and differentiation.

The paper develops a new mouse model for human microglia transplantation to study neurodegenerative diseases and makes it publicly available.

This paper demonstrates that binding antibodies to myelin oligodendrocyte glycoprotein (MOG) significantly increases their brain half-life when combined with transferrin receptor (TfR) mediated transport.

This study shows that APOE3 and APOE4 human astrocytes differentially affect Alzheimer's disease hallmarks in chimeric mice, with APOE3 reducing and APOE4 worsening pathology.

This study investigates the role of MAPT-AS1 in regulating Tau expression in human neurons and finds no evidence supporting its function as described in Simone et al.

This study shows microglia initially seed amyloid plaques in Alzheimer's disease but later help compact them, with genetic and pharmacological manipulation affecting plaque formation.

The paper compares proteomic profiles of human and mouse microglia from different sources, revealing significant differences between in vitro and ex vivo cultures.

The paper uses single-molecule detection and super-resolution imaging to analyze how four monoclonal antibodies bind to beta-amyloid aggregates, finding Lecanemab has superior binding properties.

This study examines how APOE isoforms affect the transcriptomic and epigenomic features of human microglia in an Alzheimer's disease xenotransplantation model, identifying genotype-dependent differences.

This study compares two high-resolution spatial transcriptomics platforms in an AD mouse model to characterize the amyloid plaque cell niche and its cellular responses.

This study identifies distinct microglial responses to amyloid-beta in AD using single-cell data, highlighting HLA-related and cytokine responses and their genetic modulation.

This study investigates the role of PSENEN in the gamma-secretase complex, showing its structural and functional importance in complex formation and cleavage activity.

The paper shows that astrocyte calcium dysfunction leads to early network hyperactivity in Alzheimer's Disease, which can be reversed by restoring calcium signaling.

This paper introduces an automated AI-driven system for continuous phenotyping of mouse cognition and behaviour, showing it can distinguish hippocampal and Alzheimer's models better than standard tests.

This study compares microglial DKK2 expression in mouse AD models and human AD brains, finding upregulation in mice but not in humans.

The paper shows that MEG3, a long noncoding RNA, induces necroptosis in human neurons exposed to amyloid pathology, mimicking AD features in a xenograft model.

The paper transplants human iPSC-derived astrocytes into mouse brains to study their response to amyloid-β plaques, finding morphological changes independent of APOE alleles.

This study identifies impaired MCH-system function in AD models and patients, disrupting synaptic downscaling and neuronal activity stability.

This study shows that the AppNL-G-F mouse retina accumulates Aβ early and exhibits AD-like features, suggesting it as a model for preclinical AD research and diagnosis.

The paper uses spatial transcriptomics and in situ sequencing to study gene networks in the amyloid-β plaque niche of AD, revealing microglia-astroglia interactions and myelination abnormalities.

The paper shows that single nucleus RNA-Seq fails to detect microglial activation genes in human brain samples compared to single cell RNA-Seq.

This study identifies miR-132 deficiency as a cause of impaired adult hippocampal neurogenesis in Alzheimer's disease and shows that restoring miR-132 levels can reverse these deficits and memory issues.

The paper identifies AD risk genes that influence microglia response to amyloid-β but not TAU pathology in mouse models.

The paper demonstrates that human microglia derived from embryonic stem cells can engraft mouse brains and express Alzheimer's risk genes when exposed to Aβ, offering a new model to study genetic risk in AD.

The paper demonstrates that AAV-delivered VHH-B9 reduces amyloid beta levels in an Alzheimer’s disease mouse model.