Author

Daan Moechars

VIB-KU Leuven Center for Brain & Disease ResearchORCID 0000-0002-0079-9778Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Bart De StrooperiD· 3 shared Mark W. E. J. FiersiD· 3 shared Dietmar Rudolf ThaliD· 2 shared Anna MallachiD· 1 shared Ben VermaerckeiD· 1 shared Bert HoubeniD· 1 shared Brajabandhu PradhaniD· 1 shared Disha ShahiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Bart De StrooperORCID

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3 papers

Recent·Most cited

Phagocytes as Plaque Catalysts: Human Macrophages Actively Generate Pathogenic Aβ42 Fibrils with Seeding and Cross-Seeding Potency

Katerina Konstantoulea, Meine Ramakers, Sarah Catherine Borrie, Dries T’Syen, Daan Moechars, Małgorzata Alicja Śliwińska, Brajabandhu Pradhan, Giulia Albertini, Grigoria Tsaka, Bert Houben, Mark W. E. J. Fiers, Maarten Dewilde, Dietmar Rudolf Thal, Willem Michael, Jonas J. Neher, , Joost W. H. Schymkowitz

This study shows human macrophages and microglia actively produce Aβ42 fibrils, which seed amyloid plaques and tau aggregation, and this process is influenced by genetic factors like TREM2.

bioRxiv · Oct 11, 2025 · PreprintBiochemistry

Applying high-resolution spatial transcriptomics to characterise the amyloid plaque cell niche in Alzheimer's Disease

Anna Mallach, Magdalena Zielonka, Veerle van Lieshout, Yanru An, Jia Hui Khoo, Marisa Vanheusden, Wei-Ting Chen, Daan Moechars, I. Lorena Arancibia‐Cárcamo, Mark W. E. J. Fiers, Bart De Strooper

This study compares two high-resolution spatial transcriptomics platforms in an AD mouse model to characterize the amyloid plaque cell niche and its cellular responses.

Cell Reports · May 30, 2024Peer-reviewedNeuroscience

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's Disease

Disha Shah, Willy Gsell, Jérôme Wahis, Emma Susanne Luckett, Tarik Jamoulle, Ben Vermaercke, Pranav Preman, Daan Moechars, Véronique Hendrickx, Tom Jaspers, Katleen Craessaerts, Katrien Horré, Leen Wolfs, Mark W. E. J. Fiers, Matthew G. Holt, , Bart De Strooper

The paper shows that astrocyte calcium dysfunction leads to early network hyperactivity in Alzheimer's Disease, which can be reversed by restoring calcium signaling.

Cell Reports · Aug 1, 2022Peer-reviewedNeuroscience