Lipi Thukral

The paper shows LC3B forms nanoclusters on autophagosomes via specific lipid interactions and a unique binding pocket, impacting autophagosome motility.

This study identifies a lipid-triggered allosteric site in LC3 that modulates receptor binding activity through conformational changes upon membrane engagement.

This study presents whole-genome and transcriptome analyses of breast tumors from India, identifying novel mutations, copy number alterations, and subtypes with clinical implications.

This study determines the cryo-EM structure of p62 and visualizes its filament organization and calcium-rich lipid droplet cargo in cells under stalled autophagy.

The paper identifies a mutation P812S in SARS-CoV-2 associated with immune evasion and upper airway adaptation, but reduced syncytia formation.

The paper analyzes intra-host Single Nucleotide Variations (iSNVs) in SARS-CoV-2 genomes across multiple time points and regions, finding that many iSNVs later become population-level variants and some may contribute to immune escape.

The paper investigates how CDK5 phosphorylates cPLA2 in Parkinson's Disease, leading to neuroinflammation and identifies potential therapeutic targets.

The paper identifies mutational patterns in SARS-CoV-2 spike protein using genomic and structural data, finding structural changes that may affect vaccine efficacy.

The paper identifies a mutation in the papA2 gene of Mycobacterium tuberculosis that leads to loss of sulfolipids by disrupting protein stability and structure.