Dwayne D. Simmons

Cochlear Innate Immune Homeostasis is altered in the Oncomodulin-Deficient Mouse Model

This study examines how the absence of oncomodulin in mice affects cochlear innate immunity, finding changes in macrophage density and morphology without significant cytokine differences.

Lack of Oncomodulin Increases ATP-Dependent Calcium Signaling and Susceptibility to Noise in Adult Mice

This study shows that lack of oncomodulin in adult mice increases ATP-dependent calcium signaling and susceptibility to noise-induced hearing loss.

Oncomodulin Regulates Spontaneous Calcium Signaling and Maturation of Afferent Innervation in Cochlear Outer Hair Cells

This study shows that Oncomodulin modulates spontaneous calcium signaling and afferent innervation maturation in cochlear outer hair cells during development.

Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells.

This study shows that OCM uniquely regulates intracellular Ca2+ signaling in neonatal cochlear outer hair cells by slowing Ca2+ kinetics and reducing free [Ca2+]i.

Diminished GAD67 Terminals and Ambient GABA Inhibition Associated with Reduced Motor Neuron Recruitment Threshold in the SOD1G93A ALS mouse

The paper examines age-dependent changes in inhibitory terminals and GABA inhibition in SOD1G93A ALS mouse motor neurons, finding reduced GAD67 terminals and ambient GABA inhibition in vulnerable motor pools.

Oncomodulin Delays Age-Related Hearing Loss in C57 and CBA Mice

This study shows that Oncomodulin prevents early progressive hearing loss in C57 and CBA mice by maintaining Ca2+ signaling in outer hair cells.

Spontaneous and coordinated Ca2+ activity of cochlear sensory and non-sensory cells drives the maturation of OHC afferent innervation

The paper shows that spontaneous Ca2+ signals from OHCs and non-sensory cells coordinate to refine OHC afferent innervation during development.