GenomicsGenome ResearchPeer-reviewed
The rescue of epigenomic abnormalities in ICF1 patient iPSCs following DNMT3B correction is incomplete at a residual fraction of H3K4me3-enriched regions
Varsha Poondi Krishnan, Barbara Morone, Shir Toubiana…·Maria Rosaria Matarazzo
The study corrects DNMT3B mutations in ICF1 iPSCs and finds that while most hypomethylated regions are restored, some regions remain hypomethylated and show increased H3K4me3 and CTCF motifs.
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