Maria Rosaria Matarazzo

ZNF687 couples bone marrow myeloid progenitor dynamics toosteoclastogenesis in severe Paget's disease of bone

This study shows ZNF687 regulates bone marrow myeloid progenitor dynamics and osteoclastogenesis, linking its loss to reduced osteoclast differentiation and increased trabecular bone mass in a mouse model.

A novel iPSC-based model of ICF syndrome subtype 2 recapitulates the molecular phenotype of ZBTB24 deficiency

The paper develops an iPSC model of ICF2 syndrome to study ZBTB24 deficiency's effects on DNA methylation and cellular function.

The rescue of epigenomic abnormalities in ICF1 patient iPSCs following DNMT3B correction is incomplete at a residual fraction of H3K4me3-enriched regions

The study corrects DNMT3B mutations in ICF1 iPSCs and finds that while most hypomethylated regions are restored, some regions remain hypomethylated and show increased H3K4me3 and CTCF motifs.