Monika Krzak

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

The paper identifies molecular signatures of Crohn's disease using scRNA-seq data from terminal ileal biopsies, highlighting key cell types and pathways involved in disease pathogenesis.

The paper maps cell-type-specific eQTLs in IBD patients to identify effector genes and mechanisms linking genetic risk to disease.

The paper identifies inflammation-associated monocytes (IAMs) in IBD and experimental colitis, showing they express ACOD1 to limit cytokine production during inflammation.

The study corrects DNMT3B mutations in ICF1 iPSCs and finds that while most hypomethylated regions are restored, some regions remain hypomethylated and show increased H3K4me3 and CTCF motifs.