Varsha Poondi Krishnan

ENDOTHELIAL GENE REGULATORY ELEMENTS ASSOCIATED WITH CARDIOPHARYNGEAL LINEAGE DIFFERENTIATION

The paper identifies endothelial regulatory elements associated with cardiopharyngeal lineage differentiation using chromatin remodeling data, gene expression, and machine learning.

Cardiac Outflow tract septation defects in a DiGeorge syndrome model respond to Minoxidil treatment.

The paper shows that Minoxidil treatment reduces cardiac outflow tract septation defects in a Tbx1 mutant mouse model of DiGeorge syndrome by inhibiting collagen cross-linking.

The rescue of epigenomic abnormalities in ICF1 patient iPSCs following DNMT3B correction is incomplete at a residual fraction of H3K4me3-enriched regions

The study corrects DNMT3B mutations in ICF1 iPSCs and finds that while most hypomethylated regions are restored, some regions remain hypomethylated and show increased H3K4me3 and CTCF motifs.