Author

David C. Uhlfelder

Johannes Gutenberg University Mainz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 1

Frequent Co-Authors

Ari WaismaniD· 4 shared Michaela Blanfeld· 3 shared Carsten SchelmbaueriD· 2 shared David AndruszewskiiD· 2 shared Emmanouil StylianakisiD· 2 shared Ilgiz A. MufazaloviD· 2 shared Nadine HövelmeyeriD· 2 shared Abdelrahman ElwyiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersImmunology

Ari WaismanORCID

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4 papers

Recent·Most cited

Targeting soluble immunoglobulins ameliorates idiopathic multicentric Castleman disease in a mouse model

David C. Uhlfelder, David Andruszewski, Leon R Amelong, Helena S Schafer, Mia Huttenschmidt, Michaela Blanfeld, Carsten Schelmbauer, Zeynep Ergün, Aysan Poursadegh Zonouzi, Anne Hausen, S. Zimmer, Matthias M. Gaida, Saskia von Ungern-Sternberg, Kerstin Jurk, Frank Thomas Wunderlich, , Ilgiz A. Mufazalov

This paper develops a mouse model of idiopathic multicentric Castleman disease (iMCD) by targeting IL-6 to Foxp3+ Treg cells, showing that reducing soluble immunoglobulin production alleviates disease symptoms and improves survival.

bioRxiv · Jul 29, 2026 · PreprintImmunology

Prohibitin 2 is a Key Regulator of T Cell Proliferation, Differentiation, and Effector Functions in vivo

Johannes F. Vogt, Carsten Merkwirth, Petra Adams‐Quack, Elena Zurkowski, Emmanouil Stylianakis, David C. Uhlfelder, Thomas Michna, Assel Nurbekova, Ute Distler, Liliana Rojas-Charry, Hajime Yurugi, Sonja Reißig, F Wunderlich, Krishnaraj Rajalingam, Stefan Tenzer, , Nadine Hövelmeyer

This study investigates the role of PHB2 in T cell proliferation, differentiation, and effector functions, finding that PHB2 deficiency causes cell cycle arrest and metabolic dysfunction.

Communications Biology · Jul 20, 2026Peer-reviewedImmunology

B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the anti-viral CD8+ T cell response

Xinyuan Liu, Filiz Demircik, Mariia Antipova, Emmanouil Stylianakis, Matthias Klein, David Alejandro Bejarano, Abdelrahman Elwy, Anna Ebering, Michaela Blanfeld, Katlynn Carter, Lisa Johann, David C. Uhlfelder, Elisa Blickberndt, Yao Chen, Hans Christian Probst, , Ari Waisman

This study shows B cells sustain Langerin+ cDC1s via LTβ and MMMs to support anti-viral CD8+ T cell responses during MCMV infection.

Cellular and Molecular Immunology · Feb 24, 2026Peer-reviewedImmunology

Embryo-restricted responses to maternal IL-17A promote neurodevelopmental disorders in mouse offspring

David Andruszewski, David C. Uhlfelder, Genni Desiato, Tommy Regen, Carsten Schelmbauer, Michaela Blanfeld, Lena Scherer, Konstantin Radyushkin, Davide Pozzi, Ari Waisman, Ilgiz A. Mufazalov

This study establishes a novel mouse model of prenatal IL-17A imprinting, showing embryo-restricted responses lead to behavioral deficits in offspring.

Molecular Psychiatry · Oct 9, 2024Peer-reviewedNeuroscience