David John Deehan

This study uses single-cell proteomics to identify protein-defined chondrocyte states and other cell populations in human osteoarthritic joints, complementing single-cell transcriptomics.

The paper identifies and functionally validates dynamically accessible chromatin regions in response to IL-1 stimulation using ATAC-seq and CRISPR/Cas9.

This study investigates the functional effects of the OA-associated SNP rs11780978 on PLEC methylation and expression across multiple tissues, revealing tissue-specific impacts.