Jolet Y. Mimpen

This study uses single-cell proteomics to identify protein-defined chondrocyte states and other cell populations in human osteoarthritic joints, complementing single-cell transcriptomics.

This study identifies 20 genetic loci associated with knee alignment and shows genetic correlation with knee osteoarthritis, suggesting osteoarthritis may causally influence alignment.

This study uses spatial and single-cell transcriptomics to map cellular changes in human tendons across development and aging, identifying lineage-specific targets for therapeutic repair.

The paper creates a single-cell atlas of the healthy human Achilles tendon, identifying six fibroblast subtypes with distinct spatial distributions and transcriptional profiles.

This study uses single-nucleus RNA sequencing to analyze early cellular changes in human quadriceps tendons after rupture, identifying key cell types and pathways involved in the injury response.