Sarah J. Rice

This study uses single-cell proteomics to identify protein-defined chondrocyte states and other cell populations in human osteoarthritic joints, complementing single-cell transcriptomics.

This study identifies 20 genetic loci associated with knee alignment and shows genetic correlation with knee osteoarthritis, suggesting osteoarthritis may causally influence alignment.

This study quantifies DNA methylation changes during human articular cartilage development and identifies epigenomic mediators of osteoarthritis risk in prenatal joint tissues.

This study investigates the functional effects of the OA-associated SNP rs11780978 on PLEC methylation and expression across multiple tissues, revealing tissue-specific impacts.

The paper functionally tests osteoarthritis-associated variants to identify regulatory activity, finding six SNPs with differential effects, including rs4730222 increasing HBP1 isoform expression.