Author

Matthew James Bottomley

University of OxfordORCID 0000-0001-5793-4777Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Girishkumar Kaitholil KumaraniD· 2 shared Adil Siraj LakhaiD· 1 shared Adrian Baez‐OrtegaiD· 1 shared Ahmet HaziniiD· 1 shared Alex Nicolas Gordon-WeeksiD· 1 shared Andrew R. J. LawsoniD· 1 shared Areeb MianiD· 1 shared Cara R. BrodieiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Girishkumar Kaitholil KumaranORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintDec 11, 2025

Machine perfusion and single-cell spatial transcriptome mapping identifies novel immune escape mechanisms in colorectal cancer liver metastasis

Peter Kok-Ting Wan, Ranchu Cheng, David Johnson…·Alex Nicolas Gordon-Weeks

DOI 10.64898/2025.12.09.693114

humanspatial transcriptomics

𝕏 PostBluesky

ImmunologybioRxivPreprintJan 20, 2025

Immune and Mutational Profile of Gene-Edited Low-Immunogenic Human Primary Cholangiocyte Organoids

Sandra Petrus-Reurer, Adrian Baez‐Ortega, Winnie Lei…·Kourosh Saeb‐Parsy

This study generates HLA-edited cholangiocyte organoids with reduced immunogenicity and reports their mutation profiles and immune response in vitro and in vivo.

DOI 10.1101/2025.01.20.628680

humanbulk RNA-seq

𝕏 PostBluesky