Author

Zhonghui Lin

Fuzhou UniversityORCID 0000-0001-5797-7347Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Danping Zhang· 1 shared Haishan GaoiD· 1 shared Liyang DuiD· 1 shared Mengquan YangiD· 1 shared Ruyi Shi· 1 shared Yusong LiuiD· 1 shared Zhipu LuoiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 9 mutual co-author links

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1 shared paperMolecular Biology

Danping Zhang

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 25, 2025

Mechanistic Insights into Cyclic Penta-Adenylate-Mediated Activation of Type III CRISPR Ribonuclease Csm6

Ruyi Shi, Mengquan Yang, Yusong Liu…·Zhonghui Lin

This study identifies cA5 as the activator for ApCsm6, a type III CRISPR ribonuclease, and reveals its structural basis for cA5-selective recognition and self-limiting activity through Cryo-EM structures.

DOI 10.1101/2025.10.25.684504

experimental assayprotein folding & dynamics

𝕏 PostBluesky

Molecular BiologyNucleic Acids ResearchPeer-reviewedFeb 4, 2023

Molecular basis of stepwise cyclic tetra-adenylate cleavage by the type III CRISPR ring nuclease Crn1/Sso2081

Liyang Du, Danping Zhang, Zhipu Luo, Zhonghui Lin

This study determines the crystal structures of Crn1/Sso2081 in different states to elucidate the mechanism of cA4 cleavage by the type III CRISPR ring nuclease.

11 citations

experimental assay

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