Mechanistic Insights into Cyclic Penta-Adenylate-Mediated Activation of Type III CRISPR Ribonuclease Csm6
Ruyi Shi, Mengquan Yang, Yusong Liu, Haishan Gao, Zhonghui Lin
This study identifies cA5 as the activator for ApCsm6, a type III CRISPR ribonuclease, and reveals its structural basis for cA5-selective recognition and self-limiting activity through Cryo-EM structures.
bioRxiv · Oct 25, 2025 · PreprintBiochemistry