Author

Haishan Gao

Westlake UniversityORCID 0000-0002-4954-8793Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Mengquan YangiD· 2 shared Yusong LiuiD· 2 shared Ao Qi· 1 shared Hongtao YuiD· 1 shared Maozhou HeiD· 1 shared Ping LüiD· 1 shared Qiuqin ZhangiD· 1 shared Ruyi Shi· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiochemistry

Mengquan YangORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 25, 2025

Mechanistic Insights into Cyclic Penta-Adenylate-Mediated Activation of Type III CRISPR Ribonuclease Csm6

Ruyi Shi, Mengquan Yang, Yusong Liu…·Zhonghui Lin

This study identifies cA5 as the activator for ApCsm6, a type III CRISPR ribonuclease, and reveals its structural basis for cA5-selective recognition and self-limiting activity through Cryo-EM structures.

DOI 10.1101/2025.10.25.684504

experimental assayprotein folding & dynamics

𝕏 PostBluesky

BiophysicsbioRxivPreprintMay 31, 2025

Cryo-EM structure of DNA-unbound human MCM2-7 complex reveals new disease-relevant regulation

Yusong Liu, Mengquan Yang, Ping Lü…·Hongtao Yu

The paper reveals a safety latch mechanism in the DNA-unbound MCM2-7 complex that blocks DNA entry and can be disrupted by mutations, leading to replication defects and DNA damage.

DOI 10.1101/2025.05.31.656953

humancryo-EM

𝕏 PostBluesky