Mengquan Yang

This study identifies cA5 as the activator for ApCsm6, a type III CRISPR ribonuclease, and reveals its structural basis for cA5-selective recognition and self-limiting activity through Cryo-EM structures.

The paper reveals a safety latch mechanism in the DNA-unbound MCM2-7 complex that blocks DNA entry and can be disrupted by mutations, leading to replication defects and DNA damage.

This study combines transcriptomics and metabolomics to identify key genes and metabolites involved in drought tolerance mechanisms in Nicotiana tabacum under varying drought conditions.