Chen‐Hao Yeh

The paper investigates whether genetically diverse B-cell receptor responses in simian-HIV infected macaques converge functionally, finding that functional convergence does not require genetic convergence.

This study shows that mitochondrial apoptosis limits non-proliferating and defective B cell states in germinal centers without affecting affinity maturation.

The paper shows that boosting at the same site as the initial immunization preferentially engages bnAb lineage precursors in secondary germinal centers, while contralateral boosting recruits naive and non-specific memory B cells.