Garnett H. Kelsoe

Functional Convergence of Genetically Diverse B-Cell Receptors in Simian-HIV Infected Rhesus Macaques

The paper investigates whether genetically diverse B-cell receptor responses in simian-HIV infected macaques converge functionally, finding that functional convergence does not require genetic convergence.

Apoptotic Quality Control of Cellular Competence Limits Cryptic Germinal Center B Cell States

This study shows that mitochondrial apoptosis limits non-proliferating and defective B cell states in germinal centers without affecting affinity maturation.

Asymmetric Boost Responses to an HIV-1 Vaccine: Boost-site Controls Secondary B-cell Fates

The paper shows that boosting at the same site as the initial immunization preferentially engages bnAb lineage precursors in secondary germinal centers, while contralateral boosting recruits naive and non-specific memory B cells.

Antibody feedback limits specific B-cell entry and alters germinal center repertoires by antibody-antigen complexes

The paper shows that passive antibody feedback reduces RBS-specific GC B cells and increases unspecific B cells, with no effect on primary GC response magnitude.

Profiling Allogeneic HLA-specific B-cell Responses Utilizing a 64-plex Single-HLA Reporter Cell Panel

The paper develops a 64-plex single-HLA reporter cell panel and analysis tool to identify and characterize allogeneic HLA-specific B cells in sensitized individuals.

Iterative immunogen optimization to focus elicited responses on a conserved, subdominant influenza hemagglutinin epitope

The paper designs immunogens that redirect immune responses to a conserved influenza epitope using iterative machine learning and in vivo testing.

Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases

The paper develops fluorescence-barcoded cell lines expressing membrane-anchored influenza neuraminidases to study antibody responses and vaccine efficacy.