Author

Keisuke Tonouchi

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Garnett H. KelsoeiD· 2 shared Kevin J. WieheiD· 2 shared Amanda EatoniD· 1 shared Barton F. HaynesiD· 1 shared Chen‐Hao YehiD· 1 shared David C. MontefioriiD· 1 shared Dongmei Liao· 1 shared Elizabeth S. Van ItallieiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

Garnett H. KelsoeORCID

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2 papers

Recent·Most cited

Asymmetric Boost Responses to an HIV-1 Vaccine: Boost-site Controls Secondary B-cell Fates

John S. Barber, Keisuke Tonouchi, Chen‐Hao Yeh, Madison Berry, Helene Fradin Kirshner, Kevin J. Wiehe, Amanda Eaton, David C. Montefiori, Ming Tian, Frederick W. Alt, Kevin O. Saunders, George M. Shaw, Barton F. Haynes, Garnett H. Kelsoe

The paper shows that boosting at the same site as the initial immunization preferentially engages bnAb lineage precursors in secondary germinal centers, while contralateral boosting recruits naive and non-specific memory B cells.

bioRxiv · Aug 19, 2026 · PreprintImmunology

Antibody feedback limits specific B-cell entry and alters germinal center repertoires by antibody-antigen complexes

Keisuke Tonouchi, Joel Finney, Emmanuel James San, Elizabeth S. Van Itallie, Joshua S. Martin Beem, Dongmei Liao, Xiaoe Liang, Ling Yuan, Scott E. Szafranski, Masayuki Kuraoka, Kevin R. McCarthy, Kevin J. Wiehe, Stephen C. Harrison, Garnett H. Kelsoe

The paper shows that passive antibody feedback reduces RBS-specific GC B cells and increases unspecific B cells, with no effect on primary GC response magnitude.

bioRxiv · Aug 4, 2026 · PreprintImmunology