NeurosciencebioRxivPreprint
Neuron-specific increase in lamin B1 disrupts nuclear function in Huntington's disease
Rafael Alcalá‐Vida, Marta García-Forn, Jordi Creus‐Muncunill…·Esther Pérez‐Navarro
This study shows increased lamin B1 levels in HD neurons disrupt nuclear function, and reducing lamin B1 with betulinic acid improves nuclear homeostasis and prevents motor and cognitive dysfunction in a mouse model.
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