Author

Guy Slater

University of CambridgeORCID 0000-0002-4202-8285Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Aled ParryiD· 2 shared Masashi NaritaiD· 2 shared Shamith SamarajiwaiD· 2 shared Yoko ItoiD· 2 shared Adelyne Sue Li ChaniD· 1 shared Carla Castany‐PladevalliD· 1 shared Dóra BiharyiD· 1 shared Enrique BlancoiD· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersMolecular Biology

Aled ParryORCID

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2 papers

Recent·Most cited

Transcription-driven cohesin repositioning rewires chromatin loops in cellular senescence

Ioana Olan, Aled Parry, Stefan Schoenfelder, Masako Narita, Yoko Ito, Adelyne Sue Li Chan, Guy Slater, Dóra Bihary, Masashige Bando, Katsuhiko Shirahige, Hiroshi Kimurâ, Shamith Samarajiwa, Peter Fraser, Masashi Narita

This study shows that oncogenic HRAS-induced senescence in human fibroblasts involves enhancer-promoter rewiring and dynamic cohesin binding, particularly at SASP genes.

Nature Communications · Nov 27, 2020Peer-reviewedMolecular Biology

Neuron-specific increase in lamin B1 disrupts nuclear function in Huntington's disease

Rafael Alcalá‐Vida, Marta García-Forn, Jordi Creus‐Muncunill, Yoko Ito, Enrique Blanco, Carla Castany‐Pladevall, Killian Crespí-Vázquez, Aled Parry, Guy Slater, Shamith Samarajiwa, Sandra Peiró, Luciano Di Croce, Masashi Narita, Esther Pérez‐Navarro

This study shows increased lamin B1 levels in HD neurons disrupt nuclear function, and reducing lamin B1 with betulinic acid improves nuclear homeostasis and prevents motor and cognitive dysfunction in a mouse model.

bioRxiv · Mar 6, 2020 · PreprintNeuroscience