Luciano Di Croce

This paper shows that extending G1 phase in cancer cells creates a therapeutic window for epigenetic drugs, with LSD1 inhibition and CDK4/6 inhibition working synergistically to induce differentiation and improve survival in AML models.

This study identifies USP7 as a critical regulator of PAX3::FOXO1 enhancers in FP-RMS and shows its inhibition reduces tumor growth.

This study identifies SMARCAD1 and TOPBP1 as regulators of heterochromatin maintenance during the transition from 2C-like to pluripotent states in mouse embryos.

This study identifies the IFNγ pathway's role in accelerating iPSC reprogramming and X-chromosome reactivation through STAT3 signaling and TET-mediated demethylation.

The paper identifies an alternative splicing event in SUZ12 that generates two PRC2 subtypes, SUZ12-S and SUZ12-L, with distinct roles in PRC2 function and H3K27 methylation.

This paper introduces Comp-ChIP-seq, a method to normalize ChIP-seq data across samples, improving reproducibility and reducing variability in genome-wide analysis.

This study shows increased lamin B1 levels in HD neurons disrupt nuclear function, and reducing lamin B1 with betulinic acid improves nuclear homeostasis and prevents motor and cognitive dysfunction in a mouse model.