Esther Pérez‐Navarro

This paper introduces 3TRS, a targeted RNA sequencing method to quantify HTT transcripts in HD models, revealing cryptic polyadenylation linked to somatic instability and CAG repeat purity.

This study shows that RTP801 mediates motor learning dysfunction in Huntington's disease by affecting synaptic plasticity, suggesting a therapeutic target through the RTP801/Akt/mTOR pathway.

This study shows increased lamin B1 levels in HD neurons disrupt nuclear function, and reducing lamin B1 with betulinic acid improves nuclear homeostasis and prevents motor and cognitive dysfunction in a mouse model.